In theory, corticosteroids should be less dangerous because they mimic the hormones your body produces naturally. Except, the volume of production is far higher than you could ever produce naturally. This disturbs your body's production of hormones. When it finds there's already too much, it stops production. Once this happens, you are completely dependent on continuing the drug. You cannot just stop taking it. You must slowly reduce the dosage to restart your body's own production.
When you take a tablet, this processes the drug through your stomach into the bloodstream and the whole body is affected. This means it's far more likely you will experience the side effects. Whenever possible, you should use a delivery system that targets the medical problem. So, for example, if you suffer from asthma, use an inhaler. This delivers the drug directly to the lung and limits the potential damage to the rest of your body. In fact, you may still have problems with inhalers but, if you regularly rinse your mouth out with water and gargle immediately after use, your mouth and throat should avoid damage. Staying with asthma, this is not to deny the use of Prednisone. But it suggests a different strategy to get the best results. For everyday use, an inhaler is best. If you have a serious attack, a short burst of Prednisone can quickly reduce inflammation of the airways and resolve the problem. This would suggest it's always better to discuss treatment with a doctor to reduce the risk of side effects.